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Tuberculosis and its relatively cheap cost, it is recommended that isoniazid be used in the initial phase alongside rifampicin, pyrazinamide, and ethambutol and the continuation phase alongside rifampicin of tb treatment, unless there is a specific contraindication or bacterial resistance is suspected.

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isoniazid, inh; pyrazinamide, pza; rifampin moderate a dose adjustment of prednisone may be necessary when administered concurrently with rifamycins, due to the potential for decreased exposure of prednisone.

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if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have diabetes, kidney problems, nerve problems eg, neuropathy or risk of nerve problems, hiv, or a history of liver problems if you have a history of alcohol or other substance abuse, have unsanitary injectable drug habits, or drink alcohol daily if you are older than 35 years old, you have recently given birth, or you have previously taken isoniazid.
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These drugs include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.

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