The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and or intensity of hypoglycemia oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme ace inhibitors, h 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors.
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in two in vitro mammalian cell assay systems l 51784y mouse lymphoma and chinese hamster lung cells , there was evidence of mutagenicity at tetracycline hydrochloride concentrations of 60 and 10 mcg ml, respectively.
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Tetracycline and doxycycline are part of a class of broad spectrum antibiotics known as tetracycline antibiotics.
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